The URP2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FERM domain containing kindlin 3, and Fermt3. This antibody recognizes Human, and Mouse antigen. The URP2 Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Function: Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
Subcellular Location: Cell projection>Podosome. Note: Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
Tissue Specificity: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
Subunit Structure: Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails).
Similarity: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.Belongs to the kindlin family